Aug 12, 2023 · Loss of Stat3 resulted in reduced LKB1 (STK11) mRNA levels protein expression, consistent with mTORC1 upregulation (Supplementary Fig. 2A, B).
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Loss of Stat3 in a Pten-null mouse prostate model leads to a reduction of LKB1/pAMPK with simultaneous activation of mTOR/CREB, resulting in metastatic disease.
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